助理教授/研究员、博导，江苏省“优秀青年”基金获得者。曾获得中国细胞生物学会未来女科学计划提名、中国免疫学会第十一届青年学者奖提名。

研究方向：1）肠道微生物及其代谢物调控宿主代谢与药物应答；2）肝脏—脂肪组织跨器官通讯与免疫代谢调控；3）人工智能与多组学驱动的代谢性疾病分型诊疗及个体化干预。致力于结合临床表型、人工智能与多组学技术，探索代谢性疾病的分型诊疗和个体化干预。

研究成果：发表SCI论文20余篇，成果以第一作者/通讯作者在Cell Metabolism、Nature Communications、Advanced Science、Clinical and Translational Medicine、Cellular and Molecular Gastroenterology and Hepatology、J Biol Chem等国际高水平学术期刊发表；申请国内外发明专利4项，授权2项，PCT国际专利授权1项。先后主持国家自然科学基金专项、面上及青年基金，江苏省自然科学优秀青年基金，以及球派体育首批“苗圃计划”人才项目等，并作为课题骨干参与国家重点研发计划重点专项和国家自然科学基金重大研究计划。

教学工作：主持面向本科生、研究生等多个专业课程；参与校级各类教学改革项目；曾获江苏省免疫学会教师教学竞赛特等奖及球派体育教师教学竞赛优秀奖等多个奖项；指导员工荣获第十九届“挑战杯”全国老员工课外学术科技作品竞赛省赛一等奖，全国老员工基础医学创新论坛全国赛区金奖、银奖，华东赛区一等奖。

中国生物物理学会代谢生物学分会青年理事

江苏省免疫学会青年工作委员会常委兼秘书长

江苏省免疫学会免疫与代谢专委会常委

Frontiers in Endocrinology、Medcomm等期刊审稿专家

1、Yue Zhao*, Chen Peng, Ying Xia, Tiejun Dong, Juan Xu, Xiaodong Shan, Xiang Zhong, Jingchuan Xue, Ziqian Bing, Pengfei Li, Jingyu Han, Yunzhong Nie, Kelei He*, Yu Cao*, Tingting Wang*. Microbial aldehyde-alcohol dehydrogenase degrades metformin to limit therapeutic response in type 2 diabetes. Cell Metab. 2026 Sep 29(26)00378-5.

2、Shuping Qiao, Shuangya Fan, Juan Xu, Zhen Xu, Chen Peng, Junxing Qu, Ziqian Bing, Shizhen Zhou, Sunan Shen, Guifang Xu*, Yue Zhao*, Tingting Wang*. Gut Mycobiota-Associated Tryptophan Catabolites Protect Against Metabolic Dysfunction-Associated Steatotic Liver Disease. Adv Sci. 2026;13(39).

3、Yue Zhao, Hong-Yu Nie, Shan Jiang, Meng-Fei Zhao, Peng Sun, Jing-Zi Zhang, Xiao-Chen Wang, Yi-Ping Tang, Ming-Jie Zou, Xian-Wen Yuan, Xi-Tai Sun, Xiao-Dong Shan, Jian He, Jiang-Huai Liu, Yan Bi, Lei Fang*, Xiao Han*, Chao-Jun Li*. Geranylgeranyl Pyrophosphate Promotes Hepatic Lipid Accumulation by Prenylation of Perilipin4. Cell Mol Gastroenterol Hepatol. 2025;19(9):101546.

4、Baochao Li, Yuqin Jin, Bingqing Zhang, Tong Lu, Jialing Li, Jingzi Zhang, Yiwen Zhou, Yanyi Wang, Caixia Zhang, Yue Zhao*, Huang Li*. Adipose tissue-derived extracellular vesicles aggravate temporomandibular joint osteoarthritis associated with obesity. Clin. Transl. Med. 2024;14:e70029.

5、Yue Zhao, Meng-Fei Zhao, Shan Jiang, Jing Wu, Jia Liu, Xian-Wen Yuan, Di Shen, Jing-Zi Zhang, Nan Zhou, Jian He, Lei Fang*, Xi-Tai Sun*, Bin Xue*, Chao-Jun Li*. Liver Governs Adipose Remodelling via Extracellular Vesicles in Response to Lipid Overload. Nat Commun. 2020;11(1):719.

6、Yue Zhao, Tian-Yu Wu, Meng-Fei Zhao, and Chao-Jun Li*. The balance of protein farnesylation and geranylgeranylation during the progression of nonalcoholic fatty liver disease. J Biol Chem. 2020 Apr 10;295(15):5152-5162.

7、Yue Zhao#,*, Meng-Fei Zhao#, Mei-Lin Yang#, Tian-Yu Wu, Cong-Jian Xu, Jing-Mei Wang, Chao-Jun Li*, Xi Li*. G-Protein-Coupled Receptor 30 Mediates the Anticancer Effects Induced by Eicosapentaenoic Acid in Ovarian Cancer Cells. Cancer Res Treat. 2020 Jul;52(3):815-829.

8、Wang X, Chen Q, Bing Z, Zhou S, Xu Z, Hou Y, Zhao Y*, Zhao S*, Wang T*. Low expression of m6A reader YTHDC1 promotes progression of ovarian cancer via PIK3R1/STAT3/GANAB axis. International Journal of Biological Sciences. 2023; 19(14): 4672-4688.

9、Danyang Chong#, Zhong Chen#, Shan Guan, Tongyu Zhang, Na Xu, Yue Zhao*, Chaojun Li*. Geranylgeranyl pyrophosphate regulates endothelial cell proliferation and anti- apoptosis during vascular development in the mouse embryo through mediating protein geranylgeranylation. J Genet Genomics. 48(2021):300-311.

10、Yue Zhao, Ya-Dong Zhang, You-You Zhang, Shu-Wen Qian, Zhi-Chun Zhang, Shu-Fen Li, Liang Guo, Yuan Liu, Bo Wen, Qun-Ying Lei, Qi-Qun Tang, Xi Li. p300-Dependent Acetylation of ATF5 Enhances C/EBPβ Transactivation of C/EBPα During 3T3-L1Differentiation. Mol Cell Biol. 2014,34(3):315-324.

11、Jia Liu#, Shan Jiang#, Yue Zhao#, Qian Sun, Jing-Zi Zhang, Di Shen, Jing Wu, Ning Shen, Xiao Fu, Xi-Tai Sun, De-Cai Yu, Jun Chen, Jian He, Ting-Ting Shi, Yi-Tao Ding, Lei Fang, Bin Xue*, Chao-Jun Li*. Geranylgeranyl diphosphate synthase (GGPPS) regulates non-alcoholic fatty liver disease (NAFLD)-fibrosis progression by determining hepatic glucose/fatty acid preference under high-fat diet conditions. J Pathol. 2018;246(3):277-288. (Commentary by Fullerton MD. Does prenylation predict progression in NAFLD? J Pathol. 2019)

12、Jing-Hui Jiang#, Yue Zhao#, Liu-Ling Xiao, Cui-Song Zhu, Shu-Fen Li, Xi Li. Activating transcription factor 5 regulates lipid metabolism in adipocytes. Science Bulletin. 2016;61(23):1802–1809.

13、Qiao-Li Tang, Shan Jiang, Wen-Jun Jia, Di Shen, Yu-Dong Qiu, Yue Zhao*, Bin Xue*, Chao-Jun Li*. Zoledronic acid, an FPPS inhibitor, ameliorates liver steatosis through inhibiting hepatic de novo lipogenesis. Eur J Pharmacol. 2017;814:169-177.

14、Dan-Dan Zhao, Jing Wu, Yin-Juan Zhao, Wei Shao, Qi Cheng, Xiao-Yan Shao, Xian-Wen Yuan, Juan Ye, Jian-Pu Gao, Mei-Ling Jin, Chao-Jun Li, Xiao-Lin Chen, Yue Zhao* and Bin Xue*. Zoledronic acid inhibits TSC2-null cell tumor growth via RhoA/YAP signaling pathway in mouse models of lymphangioleiomyomatosis. Cancer Cell Int (2020) 20:46.

15、Ruoyu Zhao , Binghao Wang, Yan Guo, Jingzi Zhang, Danqi Chen, Wei Ming He, Yong Juan Zhao , Yibing Ding , Chunyuan Jin, Chaojun Li, Yue Zhao*, Wei Ren*, Lei Fang*.Quantitative Proteomics Reveals Arsenic Attenuates Stem-Loop Binding Protein Stability via a Chaperone Complex Containing Heat Shock Proteins and ERp44. Proteomics. 2021 Aug;21(16):e2100035.

16、Jing Wu, Dandan Bu, Haiquan Wang, Di Shen, Tongyu Zhang, Weiwei Tao, Mengfei Zhao, Yue Zhao, Peng Li, Bin Xue* & Chao-Jun Li*. The rhythmic coupling of Egr-1 and Cidea regulates age-related metabolic dysfunction in the liver of male mice. Nat Commun. 2023(14):1634.

17、Zhi-Chun Zhang, Yan Liu, Liu-Ling Xiao, Shu-Fen Li, Jing-Hui Jiang, Yue Zhao, Shu-Wen Qian, Qi-Qun Tang, Xi Li. Upregulation of miR-125b by estrogen protects against non-alcoholic fatty liver in female mice. J Hepatol. 2015;63(6):1466-75.

18、Jing-Zi Zhang, Ruo-Yu Zhao, Clinton Yu, Christine L. N., Bryant Kenneth Wu, Zhi-Hong Liu, Yi-Bing Ding, Yue Zhao, Bin Xue, Zhen-Qiang Pan, Chao-Jun Li*, Lan Huang*, Lei Fang*. IKK-Mediated Regulation of the COP9 Signalosome via Phosphorylation of CSN5. J Proteome Res. 2020;19(3):1119-1130.

19、Jing-Zi Zhang, Neng Tang, Yin-Juan Zhao, Ruo-Yu Zhao, Xiao Fu, Dan-Dan Zhao, Yue Zhao, Lan Huang, Chao-Jun Li, Yu-Dong Qiu*, Bin Xue*, Lei Fang*. Global Phosphoproteomic Analysis Reveals Significant Metabolic Reprogramming in the Termination of Liver Regeneration in Mice. J Proteome Res. 2020;19(4):1788-1799.

20、Jing Wu, Wei-Wei Tao, Dan-Dan Bu, Yue Zhao, Tong-Yu Zhang, Dan-Yang Chong, Bin Xue, Zhen Xing, Chao-Jun Li. Egr-1 transcriptionally activates protein phosphatase PTP1B to facilitate hyperinsulinemia-induced insulin resistance in the liver in type 2 diabetes. FEBS Lett. 2019;593(21):3054-3063.

21、Zhi-Chun Zhang, Yuan Liu, Shu-Fen Li, Liang Guo, Yue Zhao, Shu-Wen Qian, Bo Wen, Qi-Qun Tang and Xi Li. Suv39h1 Mediates AP-2α-Dependent Inhibition of C/EBPα Expression during Adipogenesis. Mol Cell Biol. 2014;34(12):2330-8.

22、Shu-Fen Li, Liang Guo, Shu-Wen Qian, Yuan Liu, You-You Zhang, Zhi-Chun Zhang, Yue Zhao, Jian-You Shou, Qi-Qun Tang, Xi Li. G9a is Transactivated by C/EBPβ to Facilitate Mitotic Clonal Expansion during 3T3-L1 Preadipocyte Differentiation. Am J Physiol Endocrinol Metab. 2013;304(9):E990-8.

23、Yong-Juan Sang#, Qiang Wang#, Feng Zheng, Yue Hua, Xin-Ying Wang, Jing-Zi Zhang, Kang Li, Hai-Quan Wang, Yue Zhao, Min-Sheng Zhu*, Hai-Xiang Sun*, Chao-Jun Li*. Ggps1 deficiency in the uterus results in dystocia by disrupting uterine contraction. J Mol Cell Biol. 2021;13(2):116-127.

24、Dan-Dan Zhao, Jun Yuan, Qi Cheng, Ya-Ling Qi, Ke Lu, Shan-Shan Lai, Qian Sun, Yue Zhao, Lei Fang, Mei-Ling Jin, De-Ccai Yu, Yu-Dong Qiu, Chao-Jun Li, Jun Chen, Bin Xue. Evidence for a role of geranylgeranylation in renal angiomyolipoma and renal epithelioid angiomyolipoma. Oncol Lett. 2019;17(2):1523-1530. 

1.国家自然科学基金专项项目，T2341015，2024/01-2026/12，主持

2.国家自然科学基金面上项目，32271182，2023/01-2026/12，主持

3.国家自然科学基金青年基金项目，31601153，2017/01-2019/12，主持

4.江苏省科学基金优秀青年基金项目，BK20200061，2020/07-2023/06，主持

5.江苏省科学基金青年基金项目，BK20160619，2016/07-2019/06，主持

6.中国博士后基金面上项目，2016M601778，2016/01-2017/12，主持

7.中央高校基本科研业务费-国际合作交流项目、原创与交叉研究项目、国家自然科学基金培育项目、国家重点平台研究项目等，主持

8.国家重大研究计划“糖脂代谢的时空网络调控”项目，91857109，2019/01-2023/12，参与

9.国家重点研发计划重点专项，2018YFC1004700，2018/12-2021/12，参与

10.江苏省社会发展基金面上项目，BE2017708，2017/07-2020/06，参与

1.江苏省“优秀青年”基金获得者，2020

2.江苏省免疫学会教师教学竞赛特等奖，2023

3.球派体育新华报业优秀青年教师奖，2021

4.球派体育第一届球派体育教师教学竞赛优秀奖，2021

5.球派体育本科生招生先进个人，2023

6.球派体育育教融合奖，2024

7.球派体育研究生招生先进个人，2024